CONFORMATIONAL SEARCH OF IMMUNOSTIMULATING TRIPEPTIDE GLY-LEU-PHE STRUCTURE BY MOLECULAR MECHANICS METHOD.


By molecular mechanics method have been investigated the conformational properties of immunostimulating tripeptide Gly-Leu-Phe-NH2. It is shown that the spatial structure of this tripeptide can be described by set of low-energy conformations. Calculations produced the values of all dihedral angles of the backbone and side chains of the optimal conformations as well as intra- and inter-residue interaction energies.