Aims. This study aimed to investigate the relationship between social anxiety, suicidal ideation, and quality of life in substance abusers, as well as the predictive role of social anxiety and suicidal ideation. Methods. Using a correlational research design and non-probability purposive sampling, a sample of 80 drug addicts ranging in age from 18 to 50 (M = 35.01; SD = 6.90) years old were selected. The participants completed the Liebowitz Social Anxiety Scale (Leibowitz, 1987), the Scale of Suicidal Ideation (Beck et al., 1979), and the Quality-of-Life Scale (Flanagan, 1970). Results. There was a strong correlation between social anxiety and quality of life. Suicidal ideation was found to be significantly negatively correlated with quality of life. According to regression analysis, social anxiety and suicidal ideation were significant predictors of quality of life. Conclusions. This study's findings may be useful for drug users, adolescents, parents, counsellors, and therapists seeking information on drug addiction.